Reduced Rates of Post-Transplant Recurrent Hepatocellular Carcinoma in Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis.
Publication/Presentation Date
1-1-2022
Abstract
Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) has become the second leading cause of HCC-related liver transplantation in the United States. This study investigated post-transplant recurrence and survival for patients transplanted for NASH-related HCC compared to non-NASH HCC etiologies. Retrospective review of the United Network for Organ Sharing (UNOS) Organ Procurement and Transplantation Network (OPTN) database identified 7,461 patients with HCC-1,405 with underlying NASH and 6,086 with non-NASH underlying diseases. After propensity score matching (PSM) to account for patient- and tumor-related confounders 1,175 remained in each group. Primary outcomes assessed were recurrence rate and recurrence-free survival. Recurrent malignancy at 5 years post-transplant was lower in NASH compared to non-NASH patients (5.80 vs. 9.41%,
Volume
35
First Page
10175
Last Page
10175
ISSN
1432-2277
Published In/Presented At
Lamm, R., Altshuler, P. J., Patel, K., Shaheen, O., Amante, A. P., Civan, J., Maley, W., Frank, A., Ramirez, C., Glorioso, J., Shah, A., Dang, H., & Bodzin, A. S. (2022). Reduced Rates of Post-Transplant Recurrent Hepatocellular Carcinoma in Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis. Transplant international : official journal of the European Society for Organ Transplantation, 35, 10175. https://doi.org/10.3389/ti.2022.10175
Disciplines
Medicine and Health Sciences
PubMedID
35865863
Department(s)
Department of Surgery
Document Type
Article