Natural history of cerebral cavernous malformations.
Publication/Presentation Date
1-1-2017
Abstract
Cerebral cavernous malformations (CCM) are vascular abnormalities of the central nervous system with an incidence of 0.4-0.5% and an annual rate of hemorrhage ranging from 0.7% to 1%. Most lesions are located in the cerebral hemisphere but some occur in deeper locations such as the basal ganglia and pons. The most common symptoms during presentation are headache, seizures, and focal neurologic deficits. Surgery remains the most effective treatment modality for symptomatic CCM, while the management of incidental CCM remains controversial. Factors associated with increased risk of hemorrhage include being female and less than 40 years old. This finding, however, is not consistent in all natural history studies evaluated. During follow-up, the most important and consistent risk factor for rebleed was a prior hemorrhage. Here, we provide an indepth but concise review of the literature regarding the natural history of CCMs.
Volume
143
First Page
227
Last Page
232
ISSN
0072-9752
Published In/Presented At
Ene, C., Kaul, A., & Kim, L. (2017). Natural history of cerebral cavernous malformations. Handbook of clinical neurology, 143, 227–232. https://doi.org/10.1016/B978-0-444-63640-9.00021-7
Disciplines
Medicine and Health Sciences
PubMedID
28552144
Department(s)
Department of Surgery
Document Type
Article