Injectable Granular Hydrogels with Multifunctional Properties for Biomedical Applications.

Authors

Joshua E Mealy
Jennifer J Chung
Heon-Ho Jeong
David Issadore
Daeyeon Lee
Pavan Atluri MDFollow
Jason A Burdick

Publication/Presentation Date

5-1-2018

Abstract

Injectable hydrogels are useful for numerous biomedical applications, such as to introduce therapeutics into tissues or for 3D printing. To expand the complexity of available injectable hydrogels, shear-thinning and self-healing granular hydrogels are developed from microgels that interact via guest-host chemistry. The microgel properties (e.g., degradation, molecule release) are tailored through their crosslinking chemistry, including degradation in response to proteases. When microgels of varied formulations are mixed, complex release and degradation behaviors are observed, including after injection to permit cellular invasion.

Volume

30

Issue

20

First Page

1705912

Last Page

1705912

ISSN

1521-4095

Published In/Presented At

Mealy, J. E., Chung, J. J., Jeong, H. H., Issadore, D., Lee, D., Atluri, P., & Burdick, J. A. (2018). Injectable Granular Hydrogels with Multifunctional Properties for Biomedical Applications. Advanced materials (Deerfield Beach, Fla.), 30(20), e1705912. https://doi.org/10.1002/adma.201705912

Disciplines

Medicine and Health Sciences

PubMedID

29602270

Department(s)

Department of Surgery

Document Type

Article