Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery.
Publication/Presentation Date
1-1-2019
Abstract
Shear-thinning hydrogels are useful for biomedical applications, from 3D bioprinting to injectable biomaterials. Although they have the appropriate properties for injection, it may be advantageous to decouple injectability from the controlled release of encapsulated therapeutics. Toward this, composites of hydrogels and encapsulated microgels are introduced with microgels that are fabricated via microfluidics. The microgel cross-linker controls degradation and entrapped molecule release, and the concentration of microgels alters composite hydrogel rheological properties. For the treatment of myocardial infarction (MI), interleukin-10 (IL-10) is encapsulated in microgels and released from composites. In a rat model of MI, composites with IL-10 reduce macrophage density after 1 week and improve scar thickness, ejection fraction, cardiac output, and the size of vascular structures after 4 weeks when compared to saline injection. Improvements are also observed with the composite without IL-10 over saline, emphasizing the role of injectable hydrogels alone on tissue repair.
Volume
19
Issue
1
First Page
1800248
Last Page
1800248
ISSN
1616-5195
Published In/Presented At
Chen, M. H., Chung, J. J., Mealy, J. E., Zaman, S., Li, E. C., Arisi, M. F., Atluri, P., & Burdick, J. A. (2019). Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery. Macromolecular bioscience, 19(1), e1800248. https://doi.org/10.1002/mabi.201800248
Disciplines
Medicine and Health Sciences
PubMedID
30259658
Department(s)
Department of Surgery
Document Type
Article