Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling.

Authors

Peter J Altshuler
Alexis R Schiazza
Lijun Luo
Mark R Helmers
Bonirath Chhay
Jason J Han
Robin Hu
D Alan Herbst
Andrew Tsourkas
Zhiliang Cheng
Pavan Atluri MDFollow

Publication/Presentation Date

6-1-2021

Abstract

Early revascularization is critical to reduce morbidity after myocardial infarction, although reperfusion incites additional oxidative injury. Superoxide dismutase (SOD) is an antioxidant that scavenges reactive oxygen species (ROS) but has low endogenous expression and rapid myocardial washout when administered exogenously. This study utilizes a novel nanoparticle carrier to improve exogeneous SOD retention while preserving enzyme function. Its role is assessed in preserving cardiac function after myocardial ischemia-reperfusion (I/R) injury. Here, nanoparticle-encapsulated SOD (NP-SOD) exhibits similar enzyme activity as free SOD, measured by ferricytochrome-c assay. In an

Volume

4

Issue

6

ISSN

2366-3987

Published In/Presented At

Altshuler, P. J., Schiazza, A. R., Luo, L., Helmers, M. R., Chhay, B., Han, J. J., Hu, R., Herbst, D. A., Tsourkas, A., Cheng, Z., & Atluri, P. (2021). Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Advanced therapeutics, 4(6), 2100036. https://doi.org/10.1002/adtp.202100036

Disciplines

Medicine and Health Sciences

PubMedID

34179348

Department(s)

Department of Surgery

Document Type

Article