Waitlist Trends in Heart-Liver Transplantation With Updated US Heart Allocation System.
Publication/Presentation Date
12-1-2023
Abstract
BACKGROUND: In October 2018, the United States implemented a change in the donor heart allocation policy from a three-tiered to a six-tiered status system. The purpose of the current study was to examine changes in waitlist patterns among patients listed for concomitant heart-liver transplantation with implementation of the new allocation system.
METHODS: Patients listed for heart-liver transplantation between January 1, 2012, and June 30, 2021, were identified from the United Network for Organ Sharing database. Patients were grouped by era according to initial list date before or after October 18, 2018. Competing risks regression for mortality, transplantation, removal from waitlist due to illness was performed according to the method of Fine and Gray. Waitlist data were censored at 3 years from initial listing.
RESULTS: Overall, 523 patients were identified, of whom 310 were listed before (era 1, 59%) and 213 after (era 2, 41%) allocation change. Patients in era 1 were older, had more restrictive cardiomyopathy, and more preoperative inotrope use (all P < .05). However, patients in era 2 has longer ischemic times (3.5 ± 1.1 vs 3.1 ± 1.1 hours, P < .01) and more intraaortic balloon pump use (8.9% vs 3.9%, P = .016). Era 2 was associated with lower subdistribution hazard for death (hazard ratio 0.37; 95% CI, 0.13-1.02; P = .054) and increased transplantation (hazard ratio 1.35; 95% CI, 1.06-1.72; P = .015).
CONCLUSIONS: The implementation of the US donor heart allocation policy was associated with more preoperative intraaortic balloon pump use for patients listed for heart-liver transplantation. Despite that, the modern era was associated with lower waitlist mortality and more frequent transplantation, without increased risk of delisting due to illness.
Volume
116
Issue
6
First Page
1270
Last Page
1275
ISSN
1552-6259
Published In/Presented At
Iyengar, A., Weingarten, N., Herbst, D. A., Helmers, M. R., Kelly, J. J., Meldrum, D., Dominic, J., Guevara-Plunkett, S., & Atluri, P. (2023). Waitlist Trends in Heart-Liver Transplantation With Updated US Heart Allocation System. The Annals of thoracic surgery, 116(6), 1270–1275. https://doi.org/10.1016/j.athoracsur.2022.08.010
Disciplines
Medicine and Health Sciences
PubMedID
35987345
Department(s)
Department of Surgery
Document Type
Article