The Use of Nanoparticles in Otoprotection.
Publication/Presentation Date
1-1-2022
Abstract
The inner ear can be insulted by various noxious stimuli, including drugs (cisplatin and aminoglycosides) and over-acoustic stimulation. These stimuli damage the hair cells giving rise to progressive hearing loss. Systemic drugs have attempted protection from ototoxicity. Most of these drugs poorly reach the inner ear with consequent ineffective action on hearing. The reason for these failures resides in the poor inner ear blood supply, the presence of the blood-labyrinthine barrier, and the low permeability of the round window membrane (RWM). This article presents a review of the use of nanoparticles (NPs) in otoprotection. NPs were recently used in many fields of medicine because of their ability to deliver drugs to the target organs or cells. The studies included in the review regarded the biocompatibility of the used NPs by
Volume
13
First Page
912647
Last Page
912647
ISSN
1664-2295
Published In/Presented At
Barbara, M., Margani, V., Covelli, E., Filippi, C., Volpini, L., El-Borady, O. M., El-Kemary, M., Elzayat, S., & Elfarargy, H. H. (2022). The Use of Nanoparticles in Otoprotection. Frontiers in neurology, 13, 912647. https://doi.org/10.3389/fneur.2022.912647
Disciplines
Medicine and Health Sciences
PubMedID
35968304
Department(s)
Department of Surgery
Document Type
Article