Impact of allergy on phenotypic and endotypic profiles of nasal polyposis.
Publication/Presentation Date
6-1-2018
Abstract
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP).
METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging. Inflammatory endotypes were determined on biomarker analysis (IgE, IgA, IL-5, IL-9, ECP, EDN) in blood and nasal secretions. Eosinophil counts were obtained in blood, nasal secretions and polyps.
RESULTS: Phenotype and endotype profiles were comparable in patients with (n=15) or without (n=42) allergy. Only asthma with high total IgE blood concentration showed association with allergy.
CONCLUSIONS: The present results suggest that allergy is not directly involved in the clinical expression and specific inflammatory pathways of CRSwNP. New therapies target inflammation signaling pathways, and identifying accurate blood and tissue biomarkers will be the line of research most likely to improve treatment of CRSwNP.
Volume
135
Issue
3
First Page
159
Last Page
162
ISSN
1879-730X
Published In/Presented At
Mortuaire, G., Gengler, I., Balden, M., Capron, M., & Lefèvre, G. (2018). Impact of allergy on phenotypic and endotypic profiles of nasal polyposis. European annals of otorhinolaryngology, head and neck diseases, 135(3), 159–162. https://doi.org/10.1016/j.anorl.2017.11.005
Disciplines
Medicine and Health Sciences
PubMedID
29229196
Department(s)
Department of Surgery, Division of Otolaryngology
Document Type
Article