Effects of Inhaled Dexamethasone/Ciprofloxacin on Acute Subglottic Stenosis in a Rabbit Model.
Publication/Presentation Date
4-1-2025
Abstract
OBJECTIVES: Subglottic stenosis (SGS) is a challenging complication post-airway interventions. Effective preventive strategies lack sufficient evidence. This study investigated the preventive effect of inhalation therapy with dexamethasone/ciprofloxacin on acute SGS in a rabbit model.
METHODS: Twenty New Zealand White rabbits underwent subglottic injury via endoscopy and received inhalation therapy twice daily starting on the injury day. Group 1 (
RESULTS: Histological analysis revealed median cricoid lumen measurements of 20.01 ± 1.42 mm
CONCLUSION: Short-term dexamethasone/ciprofloxacin inhalation does not prevent acute SGS. No improvements in cricoid lumen diameter were found. Extended survival correlated with shorter cricoid lumen, suggesting SGS progression is time dependent.
LEVEL OF EVIDENCE: NA.
Volume
10
Issue
2
First Page
70119
Last Page
70119
ISSN
2378-8038
Published In/Presented At
Kuo, I. C., Hart, C. K., Gengler, I. M., & de Alarcón, A. (2025). Effects of Inhaled Dexamethasone/Ciprofloxacin on Acute Subglottic Stenosis in a Rabbit Model. Laryngoscope investigative otolaryngology, 10(2), e70119. https://doi.org/10.1002/lio2.70119
Disciplines
Medicine and Health Sciences
PubMedID
40291573
Department(s)
Department of Surgery, Division of Otolaryngology
Document Type
Article