Early-Stage Glottic Carcinoma in the United States: Demographics and Treatment Choice.

Publication/Presentation Date

4-1-2023

Abstract

OBJECTIVE: Limited investigation of factors potentially contributing to treatment choice in early-stage glottic carcinoma (EGC) has been performed with large-scale data. The National Cancer Database (NCDB) represents >72% of all new cancer cases in the United States. We hypothesized that NCDB variables may lend insight into treatment decisions between surgery and radiation for EGC.

METHODS: The NCDB was queried for all cases of T

RESULTS: 34,991 EGC patients received treatment: 6,687 (19%) surgery; 20,289 (58%) RT; and 8,015 (23%) surgery and RT. OR for receiving RT (vs. surgery alone) were >2 for: more advanced T stage cancers (OR 2.5 [95%CI: 2.3, 2.7]), treatment at non-academic facilities (OR 2.8, [95%CI: 2.6, 3.0]), and shorter travel distances to treatment centers (OR 2.2, [95%CI: 2.0, 2.4]). Surgery was more likely with treatment in the western US, higher income, private insurance, living in a metropolitan (vs. non-metropolitan) area, female gender, older age, and low facility volume. Hispanic ethnicity, education level, and race were not associated with treatment type in the multivariable model.

CONCLUSION: Most patients in the NCDB receive first-line treatment with radiation for EGC, and this decision is associated with various tumor, patient, and treatment facility characteristics.

LEVEL OF EVIDENCE: 4 Laryngoscope, 133:901-907, 2023.

Volume

133

Issue

4

First Page

901

Last Page

907

ISSN

1531-4995

Disciplines

Medicine and Health Sciences

PubMedID

35852500

Department(s)

Department of Surgery

Document Type

Article

Link to Full Text

Share

COinS