5-hydroxytryptamine: source of activator calcium in human basilar arteries.
Publication/Presentation Date
1-1-1985
Abstract
We performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium.
Volume
16
Issue
4
First Page
718
Last Page
720
ISSN
0039-2499
Published In/Presented At
Rusch, N. J., Chyatte, D., Sundt, T. M., Jr, & Vanhoutte, P. M. (1985). 5-hydroxytryptamine: source of activator calcium in human basilar arteries. Stroke, 16(4), 718–720. https://doi.org/10.1161/01.str.16.4.718
Disciplines
Medicine and Health Sciences
PubMedID
4024184
Department(s)
Department of Surgery
Document Type
Article