Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone.
Publication/Presentation Date
5-1-1984
Abstract
The authors have previously demonstrated that high-dose methylprednisolone (30 mg/kg intravenously every 8 hours) prevents severe chronic vasospasm in dogs. In the present study, lesser doses of methylprednisolone (15 mg/kg intravenously every 8 hours) and dexamethasone (0.1 mg/kg intravenously every 8 hours), although better than no treatment at all, were significantly less effective than the higher dose of methylprednisolone. These data suggest that methylprednisolone can prevent chronic experimental vasospasm from occurring only when given in high doses (30 mg/kg).
Volume
60
Issue
5
First Page
923
Last Page
926
ISSN
0022-3085
Published In/Presented At
Chyatte, D., & Sundt, T. M., Jr (1984). Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone. Journal of neurosurgery, 60(5), 923–926. https://doi.org/10.3171/jns.1984.60.5.0923
Disciplines
Medicine and Health Sciences
PubMedID
6716159
Department(s)
Department of Surgery
Document Type
Article