Selected physiologic compatibilities and incompatibilities between human and porcine organ systems.

Authors

Zuhaib Ibrahim MDFollow
Jamie Busch
Michel Awwad
Robert Wagner
Kevin Wells
David K C Cooper

Publication/Presentation Date

11-1-2006

Abstract

The shortage of donor organs is a major barrier to clinical organ transplantation. Although xenotransplantation is considered one of the alternatives to human organ transplantation, there are immunologic and physiologic incompatibilities between humans and pigs. With the exception of coagulation, the major potential physiologic incompatibilities relating to function of the kidney, heart, liver, lungs, pancreatic islets, and hormones are reviewed. Some of these physiologic differences can be overcome by producing genetically altered pigs to improve compatibility with humans. The possibility of producing such pigs for organ transplantation is considered.

Volume

13

Issue

6

First Page

488

Last Page

499

ISSN

0908-665X

Published In/Presented At

Ibrahim, Z., Busch, J., Awwad, M., Wagner, R., Wells, K., & Cooper, D. K. (2006). Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation, 13(6), 488–499. https://doi.org/10.1111/j.1399-3089.2006.00346.x

Disciplines

Medicine and Health Sciences

PubMedID

17059572

Department(s)

Department of Surgery

Document Type

Article