Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes.
Publication/Presentation Date
11-1-2007
Abstract
Several familial syndromes are associated with an increased incidence of nervous system tumors. Recognition of these syndromes is critical to provide optimal clinical care and genetic counseling to affected patients and their families. Identification of the genetic defects responsible for these relatively uncommon disorders has led to the improved understanding of critical molecular pathways involved in tumorigenesis and has contributed to the emergence of molecularly targeted therapeutics against cancer. The hereditary syndromes and diseases included in this review are limited to those associated with brain tumors: neurofibromatosis 1, neurofibromatosis 2, tuberous sclerosis complex, von Hippel-Lindau disease, and the less frequently encountered Cowden disease and Li-Fraumeni, Turcot's, and Gorlin's syndromes.
Volume
25
Issue
4
First Page
925
Last Page
946
ISSN
0733-8619
Published In/Presented At
Farrell, C. J., & Plotkin, S. R. (2007). Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes. Neurologic clinics, 25(4), 925–viii. https://doi.org/10.1016/j.ncl.2007.07.008
Disciplines
Medicine and Health Sciences
PubMedID
17964021
Department(s)
Department of Surgery
Document Type
Article