Subependymal giant cell astrocytoma in the absence of tuberous sclerosis: illustrative case.
Publication/Presentation Date
6-19-2023
Abstract
BACKGROUND: Subependymal giant cell astrocytoma (SEGA) is a benign intraventricular tumor classically arising near the Foramen of Monro. SEGAs almost always present as a component of tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by lesions in multiple organs.
OBSERVATIONS: A 22-year-old female with no past medical history presented with new-onset right-eye pressure, floaters in the right visual field, and pulsatile tinnitus. Imaging revealed an avidly enhancing mass abutting the right Foramen of Monro, causing obstructive hydrocephalus. Following resection, histopathological analysis identified the lesion as a SEGA. However, on further workup, the patient was found to have no genetic or clinical findings of TSC, which exemplifies a rare case of SEGA in the absence of a TSC diagnosis.
LESSONS: It is essential for physicians to be aware of the possibility of SEGA in the absence of other characteristics of TSC, which has many implications for a patient's clinical course. The authors present the seventh case of SEGA without genetic or clinical features of TSC described in the literature.
Volume
5
Issue
25
ISSN
2694-1902
Published In/Presented At
Shelley, I., Mahtabfar, A., & Farrell, C. J. (2023). Subependymal giant cell astrocytoma in the absence of tuberous sclerosis: illustrative case. Journal of neurosurgery. Case lessons, 5(25), CASE23192. https://doi.org/10.3171/CASE23192
Disciplines
Medicine and Health Sciences
PubMedID
37354433
Department(s)
Department of Surgery
Document Type
Article