Brain and lung metastasis of uterine leiomyosarcoma: illustrative case.
Publication/Presentation Date
5-8-2023
Abstract
BACKGROUND: Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%-15%. Metastases to the brain are exceptionally rare and are associated with poor survival.
OBSERVATIONS: The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival.
LESSONS: The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.
Volume
5
Issue
19
ISSN
2694-1902
Published In/Presented At
Richards, H., Alsalek, S., Laiwalla, A., Attiah, M., Harary, M., Kim, W. J., Hirt, D., & Rahman, S. U. (2023). Brain and lung metastasis of uterine leiomyosarcoma: illustrative case. Journal of neurosurgery. Case lessons, 5(19), CASE22557. https://doi.org/10.3171/CASE22557
Disciplines
Medicine and Health Sciences
PubMedID
37158392
Department(s)
Department of Surgery
Document Type
Article