Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era.
Publication/Presentation Date
9-1-2021
Abstract
It has now been nearly 15 years since the last major advance in the treatment of patients with glioma. "The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity". Autophagy is primarily a survival pathway, literally self-eating, that is utilized in response to stress (such as radiation and chemotherapy), enabling clearance of effete protein aggregates and multimolecular assemblies. Promising results have been observed in patients with glioma for over a decade now when autophagy inhibition with chloroquine derivatives coupled with conventional therapy. The application of autophagy inhibitors, the role of immune cell-induced autophagy, and the potential role of novel cellular and gene therapies, should now be considered for development as part of this well-established regimen.
Volume
28
Issue
9
First Page
971
Last Page
983
ISSN
1476-5500
Published In/Presented At
Zhang, X., Deibert, C. P., Kim, W. J., Jaman, E., Rao, A. V., Lotze, M. T., & Amankulor, N. M. (2021). Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era. Cancer gene therapy, 28(9), 971–983. https://doi.org/10.1038/s41417-020-0205-8
Disciplines
Medicine and Health Sciences
PubMedID
32759988
Department(s)
Department of Surgery
Document Type
Article