Self-powered in-stent restenosis diagnosis via magnetoelastic stents.
Publication/Presentation Date
2-1-2026
Abstract
Widely used in millions of atherosclerosis treatments, conventional metal stents, although pervasive, only provide mechanical support to narrowed arteries. However, many patients experience in-stent restenosis after implantation. Here we developed smart magnetoelastic stents that preserve mechanical functionality while enabling self-powered hemodynamic monitoring for continuous and timely diagnosis of in-stent restenosis. Using a clinical catheter, the smart stent is deployed in the swine carotid artery for in vivo hemodynamic sensing, enabling effective detection of induced stenosis through artificial intelligence-assisted signal interpretation. In vivo and in vitro studies demonstrate the biosafety of the smart stent through immune profiling, human cytokine analysis and single-cell RNA sequencing. These results underscore the smart stent's potential for seamless integration into biological systems as a reliable diagnostic tool. This platform technology could potentially revolutionize current stent technology and contribute to improved strategies for managing atherosclerosis.
Volume
5
Issue
2
First Page
155
Last Page
167
ISSN
2731-0590
Published In/Presented At
Chen, G., Kim, W. J., Yang, Y., Li, Y. R., Tian, J., Zhang, J., Zhao, X., Scott, K., Defelice, L. G., Liu, Z., Xu, J., Chung, T., Carol, J., Zhou, Y., Wang, A. C., Ajijola, O. A., Weiss, P. S., Wang, W., Li, S., Colby, G. P., … Chen, J. (2026). Self-powered in-stent restenosis diagnosis via magnetoelastic stents. Nature cardiovascular research, 5(2), 155–167. https://doi.org/10.1038/s44161-025-00773-4
Disciplines
Medicine and Health Sciences
PubMedID
41699202
Department(s)
Department of Surgery
Document Type
Article