The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study.
Publication/Presentation Date
11-1-2019
Abstract
Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Traditionally, surgical intervention has been the most common treatment for plantar fibromatosis. However, numerous studies have reported high recurrence rates of plantar fibromatosis after surgical intervention, as well as wound healing difficulties and nerve injury. Plantar fibromatosis often coexists with other superficial fibrous diseases such as Dupuytren's contracture and Peyronie's disease; immunohistochemical and ultrastructural analyses suggest a relationship between Ledderhose's disease and Dupuytren's contracture. The US Food and Drug Administration approved collagenase Clostridium histolyticum for the treatment of Dupuytren's contracture in 2010 and Peyronie's disease in 2013. This case study presents the successful treatment of Ledderhose's disease almost 4 years (45.5 months) after off-label use of collagenase C. histolyticum injection in a 22-year-old white female who had recurrent plantar fibromatosis after surgical intervention.
Volume
58
Issue
6
First Page
1281
Last Page
1284
ISSN
1542-2224
Published In/Presented At
Lehrman, J. D., Miceli, A. L. L., Tabchi, S. G., & Kaplan, M. A. (2019). The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 58(6), 1281–1284. https://doi.org/10.1053/j.jfas.2019.04.006
Disciplines
Medicine and Health Sciences
PubMedID
31679681
Department(s)
Department of Surgery
Document Type
Article