The Toxicology Investigators Consortium 2023 Annual Report.

Authors

Adrienne Hughes
Alexandra Amaducci DO, Lehigh Valley Health NetworkFollow
Sharan L Campleman
Shao Li
Mari Costantini
Meghan B Spyres
Hannah Spungen
Jessica Kent
Alyssa Falise
Rachel Culbreth
Paul M Wax
Jeffery Brent
Kim Aldy
Gillian A. Beauchamp MD, Lehigh Valley Health NetworkFollow
Matthew D. Cook DO, Lehigh Valley Health NetworkFollow
John DelBianco MD, Lehigh Valley Health NetworkFollow
Derek J. Fikse DO, Lehigh Valley Health NetworkFollow
Aaron S. Frey DO, Lehigh Valley Health NetworkFollow
Kira Galeano MD, Lehigh Valley Health NetworkFollow
Timlin Glaser MD, Lehigh Valley Health NetworkFollow
Chase Jones DO, Lehigh Valley Health NetworkFollow
Kenneth D. Katz MD, Lehigh Valley Health NetworkFollow
Natalie E. Ebeling-Koning DO, Lehigh Valley Health NetworkFollow
Andrew L. Koons DO, Lehigh Valley Health NetworkFollow
Ryan Surmaitis DO, Lehigh Valley Health NetworkFollow
Tyler Willing DO, Lehigh Valley Health NetworkFollow

Publication/Presentation Date

9-10-2024

Abstract

Since 2010, the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) has maintained the ToxIC Core Registry, a national case registry of in-hospital and clinic patient consultations submitted by medical toxicology physicians. Deidentified patient data entered into the registry includes patient demographics, reason for medical toxicology evaluation, exposure agents, clinical signs and symptoms, treatments and antidotes administered, and mortality. This fourteenth annual report provides data from 7392 patients entered into the Core Registry in 2023 by 36 participating sites comprising 61 distinct healthcare facilities, bringing the total case count to 102331 between 2010 and 2023. Ethanol was the most commonly reported exposure agent class (24.4%), followed by opioids (22.7%), non-opioid analgesics (16.7%), and antidepressants (11.7%). For the first time since the registry's initiation, in 2023, ethanol was the leading agent of exposure. There were 98 fatalities (case fatality rate of 1.3%). Additional descriptive analyses in this annual report were conducted to describe the reasons for medical toxicology consultation by age in 2023, and yearly trends for opioid and psychoactive exposures, physostigmine and rivastigmine treatments, and acetaminophen exposures treated with fomepizole.

ISSN

1937-6995

Published In/Presented At

Hughes, A., Amaducci, A., Campleman, S. L., Li, S., Costantini, M., Spyres, M. B., Spungen, H., Kent, J., Falise, A., Culbreth, R., Wax, P. M., Brent, J., Aldy, K., & Toxicology Investigators Consortium Study Group (2024). The Toxicology Investigators Consortium 2023 Annual Report. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 10.1007/s13181-024-01033-w. Advance online publication. https://doi.org/10.1007/s13181-024-01033-w

Disciplines

Medicine and Health Sciences

PubMedID

39256327

Department(s)

Department of Emergency Medicine, Department of Emergency Medicine Faculty, Department of Emergency Medicine Residents, Toxicology Division, Fellows and Residents

Document Type

Article