Prolonged toxicity in a 2-year-old after accidental ingestion of aripiprazole.
Publication/Presentation Date
2-1-2009
Abstract
Aripiprazole (Abilify), or 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy}-3,4-dihydro-2(1H)-quinolone, is a novel atypical antipsychotic possessing a long half-life. Although not a Food and Drug Administration-approved indication, low-dose aripiprazole is used to treat pediatric psychiatric conditions. Data regarding toxicity of low-dose aripiprazole ingestions in children are limited. We report the case of an accidental ingestion of two 5-mg aripiprazole tablets by a 2-year-old girl with a measured drug level of 160 ng/mL approximately 34 hours after ingestion. She exhibited marked lethargy, tremor, and tachycardia persisting over 72 hours. Emergency physicians, pediatricians, and psychiatrists should be aware of the potential for significant and prolonged toxicity in children even with relatively small-dose aripiprazole exposures.
Volume
25
Issue
2
First Page
105
Last Page
106
ISSN
1535-1815
Published In/Presented At
Melhem S, Katz K, Jameson A, Shellenbarger D, Akhtar J. Prolonged toxicity in a 2-year-old after accidental ingestion of aripiprazole. Pediatr Emerg Care. 2009 Feb;25(2):105-6. doi: 10.1097/PEC.0b013e318196faaf.
Disciplines
Medicine and Health Sciences
PubMedID
19225379
Department(s)
Department of Emergency Medicine, Department of Emergency Medicine Faculty, Toxicology Division
Document Type
Article