Four-year experience with methotrexate exposures.

Authors

Frank LoVecchio
Kenneth D. Katz MD, Lehigh Valley Health NetworkFollow
David Watts
Ian Wood

Publication/Presentation Date

9-1-2008

Abstract

INTRODUCTION: Unintentional methotrexate (MTX) acute oral overdose is rarely reported.

METHODS: We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003.

RESULTS: Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred.

DISCUSSION: Although intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.

Volume

4

Issue

3

First Page

149

Last Page

150

ISSN

1556-9039

Published In/Presented At

LoVecchio F, Katz K, Watts D, Wood I. Four-year experience with methotrexate exposures. J Med Toxicol. 2008 Sep;4(3):149-50. doi: 10.1007/BF03161192.

Disciplines

Medicine and Health Sciences

PubMedID

18821486

Department(s)

Department of Emergency Medicine, Department of Emergency Medicine Faculty, Toxicology Division

Document Type

Article