INTRODUCTION: Unintentional methotrexate (MTX) acute oral overdose is rarely reported.
METHODS: We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003.
RESULTS: Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred.
DISCUSSION: Although intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.
Published In/Presented At
LoVecchio F, Katz K, Watts D, Wood I. Four-year experience with methotrexate exposures. J Med Toxicol. 2008 Sep;4(3):149-50. doi: 10.1007/BF03161192.
Medicine and Health Sciences
Toxicology Division, Department of Emergency Medicine Faculty, Department of Emergency Medicine