The Toxicology Investigators Consortium Case Registry-the 2021 Annual Report.
Publication/Presentation Date
10-1-2022
Abstract
The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twelfth annual report summarizes the registry's 2021 data and activity with its additional 8552 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2021. Detailed data was collected from these cases and aggregated to provide information, which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.4% of cases in females, 48.2% of cases in males, and 1.4% of cases in transgender or gender non-conforming individuals. Non-opioid analgesics were the most commonly reported agent class (14.9%), followed by opioids (13.1%). Acetaminophen was the most common agent reported. Fentanyl was the most common opioid reported and was responsible for the greatest number of fatalities. There were 120 fatalities, comprising 1.4% of all cases. Major trends in demographics and exposure characteristics remained similar to past years' reports. Sub-analyses were conducted to describe new demographic characteristics, including marital status, housing status and military service, the continued COVID-19 pandemic and related toxicologic exposures, and novel substances of exposure.
Volume
18
Issue
4
First Page
267
Last Page
296
ISSN
1937-6995
Published In/Presented At
Love, J. S., Karshenas, D. L., Spyres, M. B., Farrugia, L. A., Kang, A. M., Nguyen, H., Campleman, S. L., Li, S., Wax, P. M., Brent, J., Aldy, K., & Toxicology Investigators Consortium Study Group (2022). The Toxicology Investigators Consortium Case Registry-the 2021 Annual Report. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 18(4), 267–296. https://doi.org/10.1007/s13181-022-00910-6
Disciplines
Medicine and Health Sciences
PubMedID
36070069
Department(s)
Department of Emergency Medicine, Department of Emergency Medicine Faculty, Toxicology Division
Document Type
Article