Aneurysm Formation, Growth, and Rupture: The Biology and Physics of Cerebral Aneurysms.
Publication/Presentation Date
10-1-2019
Abstract
Cerebral aneurysms (CAs) are characterized by a pathological wall structure with internal elastic lamina and media disruption, which leads to focal weakened pouches of the arterial wall. The prevalence of unruptured CAs has been estimated to be 2%-5% in the general population. During the past few decades, the pathophysiological mechanisms behind the formation, growth, and rupture of CAs have been the focus of numerous research studies. In the present review, we have summarized the inflammatory pathways, genetics, and risk factors for the formation, growth, and rupture of CAs. In addition, we have discussed the concepts of geometric indexes, flow patterns, and fluid dynamics that govern CA development.
Volume
130
First Page
277
Last Page
284
ISSN
1878-8769
Published In/Presented At
Texakalidis, P., Sweid, A., Mouchtouris, N., Peterson, E. C., Sioka, C., Rangel-Castilla, L., Reavey-Cantwell, J., & Jabbour, P. (2019). Aneurysm Formation, Growth, and Rupture: The Biology and Physics of Cerebral Aneurysms. World neurosurgery, 130, 277–284. https://doi.org/10.1016/j.wneu.2019.07.093
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31323409
Department(s)
Administration and Leadership
Document Type
Article