Anticonvulsant prophylaxis and steroid use in adults with metastatic brain tumors: summary of SNO and ASCO endorsement of the Congress of Neurological Surgeons guidelines.

Authors

• Susan M Chang
• Hans Messersmith
• Manmeet Ahluwalia
• David Andrews
• Priscilla K Brastianos
• Laurie E Gaspar
• Na Tosha N Gatson
• Justin T Jordan
• Mustafa Khasraw
• Andrew B Lassman
• Julia Maues
• Maciej Mrugala
• Jeffrey Raizer
• David Schiff
• Glen Stevens
• Ashley Sumrall
• Martin Van den Bent
• Michael A Vogelbaum

Publication/Presentation Date

3-18-2019

Abstract

BACKGROUND: The Congress of Neurological Surgeons (CNS) has developed a series of guidelines on the treatment of adults with metastatic brain tumors, including systemic therapy and supportive care topics. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.

METHODS: Two CNS Guidelines were reviewed for developmental rigor by methodologists and an independent multi-disciplinary Expert Panel was formed to review the content and assess agreement with the recommendations. The expert panel voted to endorse the two guidelines and ASCO and SNO independently reviewed and approved the ASCO/SNO guideline endorsement.

RESULTS: The ASCO/SNO Expert Panel determined that the recommendations from the CNS anticonvulsants and steroids guidelines, published January 9, 2019, are clear, thorough, and based upon the most relevant scientific evidence. ASCO/SNO endorsed these two CNS guidelines, with minor alterations.

CONCLUSIONS: Key recommendations include: prophylactic anti-epileptic drugs were not recommended for routine use; corticosteroids (specifically dexamethasone) were recommended for temporary symptomatic relief in patients with neurologic symptoms and signs related to mass effect from brain metastases.

Volume

21

Issue

4

First Page

424

Last Page

427

ISSN

1523-5866

Published In/Presented At

Chang, S. M., Messersmith, H., Ahluwalia, M., Andrews, D., Brastianos, P. K., Gaspar, L. E., Gatson, N. N., Jordan, J. T., Khasraw, M., Lassman, A. B., Maues, J., Mrugala, M., Raizer, J., Schiff, D., Stevens, G., Sumrall, A., Van den Bent, M., & Vogelbaum, M. A. (2019). Anticonvulsant prophylaxis and steroid use in adults with metastatic brain tumors: summary of SNO and ASCO endorsement of the Congress of Neurological Surgeons guidelines. Neuro-oncology, 21(4), 424–427. https://doi.org/10.1093/neuonc/noz034

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

30883663

Department(s)

Administration and Leadership

Document Type

Article