Subependymoma revisited: clinicopathological evaluation of 83 cases.

Authors

• Elisabeth J Rushing
• Patrick B Cooper
• Martha Quezado
• Maria Begnami
• Ana Crespo
• James G Smirniotopoulos
• James Ecklund
• Cara Olsen
• Mariarita Santi

Publication/Presentation Date

12-1-2007

Abstract

OBJECT: Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported.

METHODS: Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopathological features were reviewed; chromogenic in situ hybridization analysis for chromosome 22 was performed (n = 8), and patient follow-up was obtained (n = 34). Overall, the patients included 68 males and 15 females, 1.5 to 85 years of age (mean, 51.0 years). Twenty-seven cases were discovered at autopsy and the remaining were surgical specimens (n = 56). Tumors arose in the posterior fossa (n = 43), lateral ventricles (n = 37), spinal cord (2) and only one arose in the temporal horn. Tumors ranged in size from 2.0 mm to 60 mm in greatest dimension (mean, 23.0 mm). Eighteen-percent (15/83) of subependymomas exhibited a mixed histologic pattern; that is, subependymoma together with another glial tumor. The most common mixture (13/15) was subependymoma and ependymoma. Surgical excision was used in all symptomatic patients; 10 patients received radiation. Four patients developed a recurrence due to incomplete excision. All patients were without evidence of disease at the last follow-up: alive (n = 28) or dead (n = 8).

CONCLUSIONS: Age is the only variable found to be significantly associated with survival. Currently, surgical methods result in an excellent long-term clinical outcome. Subependymomas do not appear to be associated with NF2 mutations.

Volume

85

Issue

3

First Page

297

Last Page

305

ISSN

0167-594X

Published In/Presented At

Rushing, E. J., Cooper, P. B., Quezado, M., Begnami, M., Crespo, A., Smirniotopoulos, J. G., Ecklund, J., Olsen, C., & Santi, M. (2007). Subependymoma revisited: clinicopathological evaluation of 83 cases. Journal of neuro-oncology, 85(3), 297–305. https://doi.org/10.1007/s11060-007-9411-6

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

17569000

Department(s)

Administration and Leadership

Document Type

Article