An immunoregulatory function for the CD8 molecule.
Publication/Presentation Date
11-1-1989
Abstract
The molecular details of immunoregulatory phenomena associated with CD8+ T lymphocytes have not been clearly elucidated. We tested the hypothesis that the cell surface glycoprotein CD8 is itself essential in mediating the inhibitory effects associated with CD8+ T cells. For this purpose we utilized a T-cell clonal pair, consisting of a human CD8+ T-cell clone and a specific CD8- phenocopy of this clone obtained via antisense RNA mutagenesis, to modulate allogeneic responses in vitro. Our findings indicate that the expression of the CD8 molecule by the inhibitory cells is essential for down-regulation of both allogeneic proliferation and generation of cytotoxicity in mixed lymphocyte cultures. These results define an immunomodulatory function for the CD8 molecule and provide insights into the molecular basis of immunosuppression.
Volume
86
Issue
21
First Page
8512
Last Page
8515
ISSN
0027-8424
Published In/Presented At
Kaplan, D. R., Hambor, J. E., & Tykocinski, M. L. (1989). An immunoregulatory function for the CD8 molecule. Proceedings of the National Academy of Sciences of the United States of America, 86(21), 8512–8515. https://doi.org/10.1073/pnas.86.21.8512
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2510168
Department(s)
Administration and Leadership
Document Type
Article