Expression of major histocompatibility complex class I antigens in rat muscle cultures: the possible developmental role in myogenesis.
Publication/Presentation Date
9-1-1989
Abstract
The expression of major histocompatibility complex class I antigens was demonstrated on aneurally cultured rat muscle cells. Myoblasts showed constitutive expression of class I antigens on their cell surfaces. The presence of the antigens was transitory, disappearing as myoblasts fused and differentiated into multinucleate myotubes. Furthermore, antibody against rat class I antigens showed an inhibitory effect on the generation of myotubes during muscle development. Although mature myotubes did not show any detectable levels of class I antigens on their cell surface, soluble factors from concanavalin A-activated spleen cells or interferon gamma could induce the expression of class I antigens on muscle fibers. These results suggest that the expression of class I antigens on muscle cells is not only immunologically modulated but also developmentally regulated and that the antigens may play a role in cell recognition and interactions during the fusion process of myogenesis.
Volume
86
Issue
18
First Page
7007
Last Page
7011
ISSN
0027-8424
Published In/Presented At
Honda, H., & Rostami, A. (1989). Expression of major histocompatibility complex class I antigens in rat muscle cultures: the possible developmental role in myogenesis. Proceedings of the National Academy of Sciences of the United States of America, 86(18), 7007–7011. https://doi.org/10.1073/pnas.86.18.7007
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2571148
Department(s)
Administration and Leadership
Document Type
Article