Prospective Evaluation of Novel 4DCT-Ventilation Imaging for Preoperative Risk Assessment in Lung Cancer: Results of the LIME Trial.
Publication/Presentation Date
7-30-2026
Abstract
PURPOSES: Surgery is the primary treatment for early-stage lung cancer. Patients with poor preoperative lung function are at increased risk of pulmonary complications after anatomic lung resection. Surgeons determine candidacy for lung resection using pulmonary function tests (PFTs), calculating predicted postoperative PFTs (PPO PFTs) by estimating the volume of lung to be resected. Conventional PPO PFT calculations assume homogeneous lung function, which can be inaccurate. Four-dimensional computed tomography (4DCT)-ventilation is a novel imaging modality developed in radiation oncology that uses 4DCT data to calculate lung function maps. This study reports the primary outcomes of the LIME trial, a prospective clinical trial comparing 4DCT-ventilation-based PPO PFTs to conventionally measured PPO lung function.
METHODS AND MATERIALS: The trial enrolled patients with stage I-IIIa lung cancer undergoing evaluation for anatomic lung resection. Patients underwent PFTs and 4DCT imaging before and 3 months after surgery. Validated image processing techniques generated 4DCT-ventilation images using the preoperative 4DCT. We calculated 4DCT-ventilation-based PPO PFTs by scaling preoperative PFTs by the 4DCT-ventilation in the surgical volume and conventional PPO PFTs following standard-of-care methods. Concordance correlation coefficients (CCCs) compared PPO PFTs with PPO PFTs for 3 PFT measures: forced expiratory volume in the first second (FEV
RESULTS: From 2018 to 2021, 65 patients consented to the study, with 36 considered evaluable. The 4DCT-ventilation-based CCCs were 91% (FEV
CONCLUSIONS: The trial met the primary endpoint with accurate 4DCT-ventilation-based prediction. The data support further investigation in an interventional trial using 4DCT-ventilation to prospectively guide surgical decision-making in lung cancer treatment.
ISSN
1879-355X
Published In/Presented At
Wilson, L. J., Castillo, R., Castillo, E., Jones, B., Miften, M., Olsen, L., Aragam, V., Erickson, C., Young, A., Meguid, R. A., Blum, M., Grenda, T. R., Barta, J. A., Leiby, B. E., Waxweiler, T., Kavanagh, B., Mitchell, J. D., & Vinogradskiy, Y. (2026). Prospective Evaluation of Novel 4DCT-Ventilation Imaging for Preoperative Risk Assessment in Lung Cancer: Results of the LIME Trial. International journal of radiation oncology, biology, physics, S0360-3016(26)04076-9. Advance online publication. https://doi.org/10.1016/j.ijrobp.2026.07.035
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42532440
Department(s)
Administration and Leadership
Document Type
Article