Acute megakaryoblastic leukemia. Blast cell aggregates simulating metastatic tumor.
Publication/Presentation Date
11-1-1985
Abstract
Acute megakaryoblastic leukemia is a rare leukemia that can present diagnostic problems. We describe two children who have this disease and had clumps of blast cells in their bone marrow, a finding usually attributed to metastatic tumor. The megakaryocytic origin of the cells was supported by their cytochemical staining pattern (positive alpha-naphthyl acetate esterase resistant to sodium fluoride inhibition and negative alpha-naphthyl butyrate esterase) and by the presence of factor VIII-related antigen. Ultrastructural studies of blast cells from one patient demonstrated platelet peroxidase. The mechanism of blast cell clump formation in these cases is unknown; nevertheless, awareness that this feature can occur in acute megakaryoblastic leukemia may avoid a misdiagnosis of metastatic solid tumor.
Volume
109
Issue
11
First Page
1033
Last Page
1035
ISSN
0003-9985
Published In/Presented At
Pui, C. H., Rivera, G., Mirro, J., Stass, S., Peiper, S., & Murphy, S. B. (1985). Acute megakaryoblastic leukemia. Blast cell aggregates simulating metastatic tumor. Archives of pathology & laboratory medicine, 109(11), 1033–1035.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3931605
Department(s)
Administration and Leadership
Document Type
Article