Obesity: "priming" the lung for injury.
Publication/Presentation Date
8-1-2013
Abstract
Acute lung injury (ALI) is a severe inflammatory condition that develops in response to local and systemic lung challenges. To date, specific risk factors for development of ALI remain poorly defined. Recent epidemiological studies have reported obesity as an important predisposing factor in the development of this condition. Although the pathogenic mechanisms linking obesity and ALI have not been well-elucidated, emerging scientific evidence has described factors secreted by adipose tissue that have important biological activities in lung and has suggested that altered secretion of these factors during obesity contributes to increased ALI susceptibility. The objective of this manuscript is to highlight recent clinical evidence supporting the association between obesity and ALI and to discuss the posited role for adipose tissue-derived factors in the pathogenesis of this condition.
Volume
26
Issue
4
First Page
427
Last Page
429
ISSN
1522-9629
Published In/Presented At
Konter, J., Baez, E., & Summer, R. S. (2013). Obesity: "priming" the lung for injury. Pulmonary pharmacology & therapeutics, 26(4), 427–429. https://doi.org/10.1016/j.pupt.2012.03.003
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22449512
Department(s)
Administration and Leadership
Document Type
Article