An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease.
Publication/Presentation Date
6-1-2017
Abstract
The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed the presentation and etiology of common diseases. For example, steatohepatitis, directly attributable to obesity, is now the most common cause of cirrhosis in the United States. Type 2 diabetes is increasingly being diagnosed in children. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity and altered metabolism on common pulmonary diseases. Obesity has recently been identified as a major risk factor for the development of asthma and for acute respiratory distress syndrome. Obesity is associated with profound changes in pulmonary physiology, the development of pulmonary hypertension, sleep-disordered breathing, and altered susceptibility to pulmonary infection. In short, obesity is leading to dramatic changes in lung health and disease. Simultaneously, the rapidly developing field of metabolism, including mitochondrial function, is shifting the paradigms by which the pathophysiology of many pulmonary diseases is understood. Altered metabolism can lead to profound changes in both innate and adaptive immunity, as well as the function of structural cells. To address this emerging field, a 3-day meeting on obesity, metabolism, and lung disease was convened in October 2015 to discuss recent findings, foster research initiatives, and ultimately guide clinical care. The major findings arising from this meeting are reported in this document.
Volume
14
Issue
6
First Page
1050
Last Page
1059
ISSN
2325-6621
Published In/Presented At
Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguin, F., McCormack, M. C., Michelakis, E. D., Black, S. M., Jain, M., Mora, A. L., Natarajan, V., Miller, Y. I., Fessler, M. B., Birukov, K. G., Summer, R. S., Shore, S. A., … Allergy, Immunology, and Inflammation Assembly (2017). An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Annals of the American Thoracic Society, 14(6), 1050–1059. https://doi.org/10.1513/AnnalsATS.201703-263WS
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28570148
Department(s)
Administration and Leadership
Document Type
Article