Synthetic MRI for Clinical Neuroimaging: Results of the Magnetic Resonance Image Compilation (MAGiC) Prospective, Multicenter, Multireader Trial.

Authors

• L N Tanenbaum
• A J Tsiouris
• A N Johnson
• T P Naidich
• M C DeLano
• E R Melhem
• P Quarterman
• S X Parameswaran
• A Shankaranarayanan
• M Goyen
• A S Field

Publication/Presentation Date

6-1-2017

Abstract

BACKGROUND AND PURPOSE: Synthetic MR imaging enables reconstruction of various image contrasts from 1 scan, reducing scan times and potentially providing novel information. This study is the first large, prospective comparison of synthetic-versus-conventional MR imaging for routine neuroimaging.

MATERIALS AND METHODS: A prospective multireader, multicase noninferiority trial of 1526 images read by 7 blinded neuroradiologists was performed with prospectively acquired synthetic and conventional brain MR imaging case-control pairs from 109 subjects (mean, 53.0 ± 18.5 years of age; range, 19-89 years of age) with neuroimaging indications. Each case included conventional T1- and T2-weighted, T1 and T2 FLAIR, and STIR and/or proton density and synthetic reconstructions from multiple-dynamic multiple-echo imaging. Images were randomized and independently assessed for diagnostic quality, morphologic legibility, radiologic findings indicative of diagnosis, and artifacts.

RESULTS: Clinical MR imaging studies revealed 46 healthy and 63 pathologic cases. Overall diagnostic quality of synthetic MR images was noninferior to conventional imaging on a 5-level Likert scale (

CONCLUSIONS: Overall synthetic MR imaging quality was similar to that of conventional proton-density, STIR, and T1- and T2-weighted contrast views across neurologic conditions. While artifacts were more common in synthetic T2 FLAIR, these were readily recognizable and did not mimic pathology but could necessitate additional conventional T2 FLAIR to confirm the diagnosis.

Volume

38

Issue

6

First Page

1103

Last Page

1110

ISSN

1936-959X

Published In/Presented At

Tanenbaum, L. N., Tsiouris, A. J., Johnson, A. N., Naidich, T. P., DeLano, M. C., Melhem, E. R., Quarterman, P., Parameswaran, S. X., Shankaranarayanan, A., Goyen, M., & Field, A. S. (2017). Synthetic MRI for Clinical Neuroimaging: Results of the Magnetic Resonance Image Compilation (MAGiC) Prospective, Multicenter, Multireader Trial. AJNR. American journal of neuroradiology, 38(6), 1103–1110. https://doi.org/10.3174/ajnr.A5227

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28450439

Department(s)

Administration and Leadership

Document Type

Article