Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme.
Publication/Presentation Date
1-1-2019
Abstract
BACKGROUND/AIM: Several epidemiological studies have reported the chemopreventive potential of biochanin A, in cancer development and progression. We investigated the anticancer potential of combination of biochanin A and temozolomide against U-87 MG and T98 G [glioblastoma multiforme (GBM)] cells.
MATERIALS AND METHODS: We evaluated the effect of biochanin A and temozolomide treatment on cell viability, expression of survival proteins, cell cycle, cell metabolism and mitochondrial function.
RESULTS: Enhanced inhibitory effects of the combination treatment were observed on cell viability, expression of cell survival proteins EGFR, p-ERK, p-AKT, c-myc and MT-MMP1, and increased expression of the tumor suppressor, p-p53. Combination treatment also induced arrest in the G
CONCLUSION: Biochanin A significantly enhanced the anticancer efficacy of temozolomide in GBM cells.
Volume
39
Issue
1
First Page
57
Last Page
66
ISSN
1791-7530
Published In/Presented At
Desai, V., Jain, A., Shaghaghi, H., Summer, R., Lai, J. C. K., & Bhushan, A. (2019). Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme. Anticancer research, 39(1), 57–66. https://doi.org/10.21873/anticanres.13079
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30591440
Department(s)
Administration and Leadership
Document Type
Article