Cellular Metabolism in Lung Health and Disease.
Publication/Presentation Date
2-10-2019
Abstract
The lung is often overlooked as a metabolically active organ, yet biochemical studies have long demonstrated that glucose utilization surpasses that of many other organs, including the heart, kidney, and brain. For most cells in the lung, energy consumption is relegated to performing common cellular tasks, like mRNA transcription and protein translation. However, certain lung cell populations engage in more specialized types of energy-consuming behaviors, such as the beating of cilia or the production of surfactant. While many extrapulmonary diseases are now linked to abnormalities in cellular metabolism, the pulmonary community has only recently embraced the concept of metabolic dysfunction as a driver of respiratory pathology. Herein, we provide an overview of the major metabolic pathways in the lung and discuss how cells sense and adapt to low-energy states. Moreover, we review some of the emerging evidence that links alterations in cellular metabolism to the pathobiology of several common respiratory diseases.
Volume
81
First Page
403
Last Page
428
ISSN
1545-1585
Published In/Presented At
Liu, G., & Summer, R. (2019). Cellular Metabolism in Lung Health and Disease. Annual review of physiology, 81, 403–428. https://doi.org/10.1146/annurev-physiol-020518-114640
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30485759
Department(s)
Administration and Leadership
Document Type
Article