Persistence of Lassa Virus Associated With Severe Systemic Arteritis in Convalescing Guinea Pigs (Cavia porcellus).
Publication/Presentation Date
5-5-2019
Abstract
Lassa fever (LF) survivors develop various clinical manifestations including polyserositis, myalgia, epididymitis, and hearing loss weeks to months after recovery from acute infection. We demonstrate a systemic lymphoplasmacytic and histiocytic arteritis and periarteritis in guinea pigs more than 2 months after recovery from acute Lassa virus (LASV) infection. LASV was detected in the arterial tunica media smooth muscle cells by immunohistochemistry, in situ hybridization, and transmission electron microscopy. Our results suggest that the sequelae of LASV infection may be due to virus persistence resulting in systemic vascular damage. These findings shed light on the pathogenesis of LASV sequelae in convalescent human survivors.
Volume
219
Issue
11
First Page
1818
Last Page
1822
ISSN
1537-6613
Published In/Presented At
Liu, D. X., Perry, D. L., DeWald, L. E., Cai, Y., Hagen, K. R., Cooper, T. K., Huzella, L. M., Hart, R., Bonilla, A., Bernbaum, J. G., Janosko, K. B., Adams, R., Johnson, R. F., Kuhn, J. H., Schnell, M. J., Crozier, I., Jahrling, P. B., & de la Torre, J. C. (2019). Persistence of Lassa Virus Associated With Severe Systemic Arteritis in Convalescing Guinea Pigs (Cavia porcellus). The Journal of infectious diseases, 219(11), 1818–1822. https://doi.org/10.1093/infdis/jiy641
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30517671
Department(s)
Administration and Leadership
Document Type
Article