Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice.
Publication/Presentation Date
4-16-2004
Abstract
Plasmid encoded exogenous IL-12 delivered as a DNA vaccine adjuvant has been shown to improve vaccine-induced immunity. In particular, pIL-12 greatly improves antigen (Ag)-specific cytotoxic tlymphocyte (CTL) activity in immunized mice. The longevity of this response has not previously been studied in detail. We have studied the effect of co-immunization with pIL-12 on HIV gp160 and Influenza A Hemeagglutinnin-specific memory immune responses. Mice co-immunized with pIL-12 and plasmid encoded antigens maintained a greater memory response than those immunized with the plasmid antigen alone which could be measured at least 6 months after vaccination. Further, this translated to an improved outcome after challenge of long term rested mice that were previously immunized. The strength of the immune response as well as the number of Ag-specific T-cells is proportional to the number of Ag-specific cells primed by the vaccination regimen.
Volume
22
Issue
13-14
First Page
1744
Last Page
1750
ISSN
0264-410X
Published In/Presented At
Chattergoon, M. A., Saulino, V., Shames, J. P., Stein, J., Montaner, L. J., & Weiner, D. B. (2004). Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice. Vaccine, 22(13-14), 1744–1750. https://doi.org/10.1016/j.vaccine.2004.01.036
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15068858
Department(s)
Administration and Leadership
Document Type
Article