The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data.
Publication/Presentation Date
3-1-2004
Abstract
PURPOSE: The epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).
METHODS AND MATERIALS: This review highlights EGFR's role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.
RESULTS: Preclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.
CONCLUSIONS: Targeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients.
Volume
58
Issue
3
First Page
927
Last Page
931
ISSN
0360-3016
Published In/Presented At
Chakravarti, A., Dicker, A., & Mehta, M. (2004). The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data. International journal of radiation oncology, biology, physics, 58(3), 927–931. https://doi.org/10.1016/j.ijrobp.2003.09.092
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
14967452
Department(s)
Administration and Leadership
Document Type
Article