Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins.
Publication/Presentation Date
4-1-2016
Abstract
PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to pulmonary adenocarcinomas could enhance residual tumor during resection.
PROCEDURES: Mice with flank tumors received a contrast agent targeting folate receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three humans with lung adenocarcinoma.
RESULTS: The peak tumor-to-background ratio (TBR) of murine tumors was 3.9. Fluorescence peaked at 2 h and was not improved beyond 0.1 mg/kg. Traditional inspection identified 30% of mice with positive margins. Molecular imaging identified an additional 50% of residual tumor deposits (p < 0.05). The fluorescent probe visually enhanced all human tumors with a mean TBR of 3.5.
CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after tumor resection.
Volume
18
Issue
2
First Page
209
Last Page
218
ISSN
1860-2002
Published In/Presented At
Keating, J. J., Okusanya, O. T., De Jesus, E., Judy, R., Jiang, J., Deshpande, C., Nie, S., Low, P., & Singhal, S. (2016). Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins. Molecular imaging and biology, 18(2), 209–218. https://doi.org/10.1007/s11307-015-0878-9
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26228697
Department(s)
Administration and Leadership
Document Type
Article