Type 2B von Willebrand Disease in Pregnancy: A Systematic Literature Review.
Publication/Presentation Date
3-1-2021
Abstract
Our objective was to review the maternal characteristics and obstetric complications in women with type 2B von Willebrand disease (VWD). A systematic literature search was conducted using PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. We included all publications that addressed type 2B VWD in pregnancy. Our primary and secondary outcomes were incidence of postpartum hemorrhage (PPH) and incidence of thrombocytopenia in pregnancy. Two reviewers independently identified eligible studies and abstracted data including maternal characteristics, hematologic characteristics, treatment, and delivery outcomes. Twenty studies met inclusion criteria. There were 27 women (32 pregnancies) with type 2B VWD. Primary PPH was reported in 9/20 women (45%) and secondary PPH was reported in 6/13 women (46%). Thrombocytopenia in pregnancy was present in 27/28 women (96%); 23/27 women (85%) had platelet count < 100 × 10
Volume
47
Issue
2
First Page
201
Last Page
216
ISSN
1098-9064
Published In/Presented At
Makhamreh, M. M., Russo, M. L., Karl, T., Delgado, N., Lackritz, K., Skupski, D. W., & Al-Kouatly, H. B. (2021). Type 2B von Willebrand Disease in Pregnancy: A Systematic Literature Review. Seminars in thrombosis and hemostasis, 47(2), 201–216. https://doi.org/10.1055/s-0041-1723799
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33636751
Department(s)
Administration and Leadership
Document Type
Article