Morphologic assessment for glaucoma in the Multicenter Uveitis Steroid Treatment (MUST) trial.
Publication/Presentation Date
8-1-2011
Abstract
PURPOSE: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial.
METHODS: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images.
RESULTS: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ = .34). Intergrader reproducibility at the RC was better (weighted κ = .59, ICC 0.74).
CONCLUSION: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.
Volume
19
Issue
4
First Page
267
Last Page
274
ISSN
1744-5078
Published In/Presented At
Gangaputra, S. S., Altaweel, M. M., Peng, Q., Friedman, D. S., Rao, P. K., Foster, C. S., Kim, R. Y., Reed, S. B., Srivastava, S. K., Wong, I. G., Kempen, J. H., & MUST Trial Research Group (2011). Morphologic assessment for glaucoma in the Multicenter Uveitis Steroid Treatment (MUST) trial. Ocular immunology and inflammation, 19(4), 267–274. https://doi.org/10.3109/09273948.2011.583376
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21770805
Department(s)
Administration and Leadership
Document Type
Article