The Evi1, microRNA-143, K-Ras axis in colon cancer.

Authors

• Jin-Song Gao
• Yingjie Zhang
• Xiaoli Tang
• Lynne D Tucker
• Patrick M Tarwater
• Peter J Quesenberry
• Isidore Rigoutsos
• Bharat Ramratnam

Publication/Presentation Date

2-18-2011

Abstract

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

Volume

585

Issue

4

First Page

693

Last Page

699

ISSN

1873-3468

Published In/Presented At

Gao, J. S., Zhang, Y., Tang, X., Tucker, L. D., Tarwater, P. M., Quesenberry, P. J., Rigoutsos, I., & Ramratnam, B. (2011). The Evi1, microRNA-143, K-Ras axis in colon cancer. FEBS letters, 585(4), 693–699. https://doi.org/10.1016/j.febslet.2011.01.033

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

21276449

Department(s)

Administration and Leadership

Document Type

Article