Correlation of Clinical Outcomes with Quantitative Polymerase Chain Reaction DNA Copy Number in Patients with Acute Retinal Necrosis.
Publication/Presentation Date
4-1-2017
Abstract
PURPOSE: To correlate visual acuity outcomes and clinical features with quantitative PCR DNA copy number in patients with acute retinal necrosis (ARN).
METHODS: Retrospective, consecutive case series.
RESULTS: In total, 14 eyes of 13 patients were diagnosed with ARN, based on the American Uveitis Society criteria, and were followed for a mean of 324.5 days (median 250.5 days, SD ± 214 days). Anterior chamber fluid analyzed by quantitative PCR identified viral DNA in 11 of 14 eyes (78.5%). Varicella zoster virus (VZV) was identified in seven eyes (50%) and herpes simplex virus (HSV) in four eyes (28.5%). Mean DNA copy number was 7.9 × 10
CONCLUSIONS: Quantitative DNA copy number of ≥5.0 × 10
Volume
25
Issue
2
First Page
246
Last Page
252
ISSN
1744-5078
Published In/Presented At
Calvo, C. M., Khan, M. A., Mehta, S., Garg, S. J., & Dunn, J. P. (2017). Correlation of Clinical Outcomes with Quantitative Polymerase Chain Reaction DNA Copy Number in Patients with Acute Retinal Necrosis. Ocular immunology and inflammation, 25(2), 246–252. https://doi.org/10.3109/09273948.2015.1115081
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26828388
Department(s)
Administration and Leadership
Document Type
Article