In vivo modulation of oligodendrocyte function by an anti-receptor antibody.
Publication/Presentation Date
1-1-1992
Abstract
The receptor for reovirus serotype 3 (Reo3R) is biochemically, pharmacologically, and antigenically related to the adrenergic receptors. Previous studies have demonstrated that anti-Reo3R antibodies and Reo3R-binding peptides alter oligodendrocyte differentiation in culture. In the present studies, antibodies and peptides that bind the Reo3R were found to alter myelin morphology in vivo. Microinjection of purified anti-Reo3R antibody into guinea pig optic nerves produced expansion of the adaxonal oligodendrocyte cytoplasm, separation of myelin lamellae, widening of Schmidt-Lanterman clefts, myelin vesiculation, and demyelination. A divalent Reo3R-binding peptide reproduced some of these changes. Anti-Reo3R antibodies and Reo3R-binding peptides alter oligodendrocyte function in vivo resulting in myelin changes. These effects appear to be mediated directly by Reo3R perturbation, at least in part, rather than through activation of additional effector mechanisms.
Volume
60
Issue
3
First Page
151
Last Page
156
ISSN
1015-2008
Published In/Presented At
Cohen, J. A., Sergott, R. C., Williams, W. V., Hill, S. J., Brown, M. J., & Greene, M. I. (1992). In vivo modulation of oligodendrocyte function by an anti-receptor antibody. Pathobiology : journal of immunopathology, molecular and cellular biology, 60(3), 151–156. https://doi.org/10.1159/000163715
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1320894
Department(s)
Administration and Leadership
Document Type
Article