Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis.
Publication/Presentation Date
6-1-1992
Abstract
Experimental allergic neuritis, an autoimmune disease of the peripheral nervous system, is a model for human Guillain-Barré syndrome. Experimental allergic neuritis is mediated by CD4+ T cells reactive with myelin P2 protein. We demonstrate that these T cells use the same members of T-cell receptor V gene families for both their alpha (V alpha 2) and beta (V beta 8) chains as T cells that cause experimental allergic encephalomyelitis, an autoimmune disease of the central nervous system. Furthermore, these T cells appear to be idiotypically related. Therefore, completely different T-cell lines with different antigen specificities, producing entirely different diseases, share common T-cell receptors.
Volume
31
Issue
6
First Page
587
Last Page
592
ISSN
0364-5134
Published In/Presented At
Clark, L., Heber-Katz, E., & Rostami, A. (1992). Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis. Annals of neurology, 31(6), 587–592. https://doi.org/10.1002/ana.410310604
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1381167
Department(s)
Administration and Leadership
Document Type
Article