Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome.
Publication/Presentation Date
9-1-2010
Abstract
OBJECTIVE: To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS).
STUDY DESIGN: We performed a retrospective cohort study of pregnant women treated with methadone for opiate addiction who delivered live-born neonates between 1996 and 2006. Four dose groups, on the basis of total daily methadone dose, were compared (160 mg/d). The primary outcome was treatment for NAS. Symptoms of NAS were objectively measured with the Finnegan scoring system, and treatment was initiated for a score>24 during the prior 24 hours.
RESULTS: A total of 330 women treated with methadone and their 388 offspring were included. Average methadone dose at delivery was 117+/-50 mg/d (range, 20-340 mg/d). Overall, 68% of infants were treated for NAS. Of infants exposed to methadone doses160 mg/d, treatment for NAS was initiated for 68%, 63%, 70%, and 73% of neonates, respectively (P=.48). The rate of maternal illicit opiate abuse at delivery was 26%, 28%, 19%, and 11%, respectively (P=.04).
CONCLUSION: No correlation was found between maternal methadone dose and rate of NAS. However, higher doses of methadone were associated with decreased illicit opiate abuse at delivery.
Volume
157
Issue
3
First Page
428
Last Page
433
ISSN
1097-6833
Published In/Presented At
Seligman, N. S., Almario, C. V., Hayes, E. J., Dysart, K. C., Berghella, V., & Baxter, J. K. (2010). Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. The Journal of pediatrics, 157(3), 428–433.e1. https://doi.org/10.1016/j.jpeds.2010.03.033
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20472252
Department(s)
Administration and Leadership
Document Type
Article