The microRNA world: small is mighty.

Authors

• Peter Nelson
• Marianthi Kiriakidou
• Anup Sharma
• Elsa Maniataki
• Zissimos Mourelatos

Publication/Presentation Date

10-1-2003

Abstract

A new paradigm of RNA-directed gene expression regulation has emerged recently, profound in scope but arresting in the apparent simplicity of its core mechanism. Cells express numerous small ( approximately 22 nucleotide) RNAs that act as specificity determinants to direct destruction or translational repression of their mRNA targets. These small RNAs arise from processing of double-stranded RNA by the Dicer nuclease and incorporate with proteins that belong to the Argonaute family. Small RNAs might also target and silence homologous DNA sequences. The immense potential of small RNAs as controllers of gene networks is just beginning to unfold.

Volume

28

Issue

10

First Page

534

Last Page

540

ISSN

0968-0004

Published In/Presented At

Nelson, P., Kiriakidou, M., Sharma, A., Maniataki, E., & Mourelatos, Z. (2003). The microRNA world: small is mighty. Trends in biochemical sciences, 28(10), 534–540. https://doi.org/10.1016/j.tibs.2003.08.005

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

14559182

Department(s)

Administration and Leadership

Document Type

Article