Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis.
Publication/Presentation Date
6-1-2003
Abstract
Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin. In this report we strengthen this evidence, showing that Lewis rats immunized with purified skeletal muscle myosin develop EAM with the same pattern and severity as EAM induced by whole rabbit skeletal muscle homogenate (WRM). Multiple inflammatory lesions are detected histopathologically in the biceps, quadriceps, and gastrocnemius muscles. Myosin-reactive T cells from animals immunized either with myosin or with WRM have similar patterns of antigen-induced proliferation. The results show that myosin, a component of skeletal muscle, is at least one autoantigen in EAM.
Volume
74
Issue
3
First Page
238
Last Page
243
ISSN
0014-4800
Published In/Presented At
Nemoto, H., Bhopale, M. K., Constantinescu, C. S., Schotland, D., & Rostami, A. (2003). Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis. Experimental and molecular pathology, 74(3), 238–243. https://doi.org/10.1016/s0014-4800(03)00003-0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12782010
Department(s)
Administration and Leadership
Document Type
Article