Performance of Molecular Lymphosonography for Detection and Quantification of Metastatic Involvement in Sentinel Lymph Nodes.
Publication/Presentation Date
8-1-2019
Abstract
OBJECTIVES: To assess the performance of molecular lymphosonography with dual-targeted microbubbles in detecting and quantifying the metastatic involvement in sentinel lymph nodes (SLNs) using a swine melanoma model.
METHODS: Targeted microbubbles were labeled with P-selectin and α
RESULTS: Thirty-five SLNs and 34 non-SLNs from 13 Sinclair swine were included in this study. Twenty-one SLNs (62%) were malignant, whereas 100% of non-SLNs were benign. The sensitivity of B-mode imaging for metastatic LN diagnosis for both readers was relatively high (90% and 71%), but the specificity was very poor (50% and 58%). The sensitivity and specificity of molecular lymphosonography for metastatic LN detection were 91% and 67%, respectively. The mean intensities from dual-targeted microbubbles correlated well with the degree of metastatic LN involvement (r = 0.6; P < 0.001).
CONCLUSIONS: Molecular lymphosonography can increase the specificity of metastatic LN detection and provide a measure to quantify the degree of metastatic involvement.
Volume
38
Issue
8
First Page
2103
Last Page
2110
ISSN
1550-9613
Published In/Presented At
Nam, K., Stapp, R., Liu, J. B., Stanczak, M., Forsberg, F., O'Kane, P. L., Lin, Z., Zhu, Z., Li, J., Solomides, C. C., Eisenbrey, J. R., & Lyshchik, A. (2019). Performance of Molecular Lymphosonography for Detection and Quantification of Metastatic Involvement in Sentinel Lymph Nodes. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 38(8), 2103–2110. https://doi.org/10.1002/jum.14906
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30589454
Department(s)
Administration and Leadership
Document Type
Article